Contract testing and manufacturing services to
support development through commercialization

Custom virus production is a critical component of assay design and biologic production for many different types of therapeutics including vaccines, gene therapy vectors and recombinant proteins.

Virus production encompasses both viral expression and virus purification. BioReliance has extensive experience in cell culture development and downstream purification for virus production in mammalian cell lines.  This includes small-scale pilot projects as well as production-size bioreactors.

Virus production services include:

• Cell extracts
• Purified Viral Preparations
• Quantified Samples
• Viral Extracts
• Purified Proteins

BioReliance research professionals have performed thousands of virus production assays for clients in Biopharma. We can provide a fast turn around time and the highest quality testing.

Contact our experienced scientific staff to learn about virus production for your project needs.

What types of viruses can be made?

BioReliance specializes in virus production and can grow/purify many different types of viruses from multiple mammalian cell lines. We also specifically can tailor a virus production assay to suit your development needs.

Recent projects have included:

• Adenovirus
• Retrovirus
• Reovirus
• Vaccinia virus
• Herpes virus
• Influenza
• Sendai virus

We can optimize viral expression and harvest conditions to manufacture lots at a cGMP production site. Please inquire with our viral production team to meet your development needs.

We also offer a wide variety of cell lines to optimize virus expression and provide high quality, purified virus for research, development, and diagnostics. BioReliance professionals also can produce viral like particles (VLP) from mammalian cell lines, if required.

What types of assays are used for virus production?

Viral recognition assays constitute a key component to quantitative virus production. BioReliance uses a number of virus production assays to ensure viral expression and isolation.

These assays include:

• Plaque Assay
• Plaque Inhibition Assay
• Hemagglutination Assay
• Neurominidase Assay
• Quantitative PCR

BioReliance is one of the world’s leading CROs, offering multiple virus production assays aimed at virus purification and viral expression.

Quality Control for Virus Production

Quality Control testing is a critical part of the production process of an infectious agent. Our viral purification process involves exhaustive sterility testing on every custom virus product. BioReliance also provides quantitative measurement of QC including protein concentration, infectivity titer, and virus particle count.

Contact our experienced scientific staff about working with your custom virus production needs.