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Darryl L. Goss joins Bioreliance
Darryl L. Goss has been appointed Vice
President, Toxicology/Laboratory Animal Diagnostic Services (LADS), a new executive position created to lead this newly
formed Business Unit.
Click here to read the
press release.
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Determining the safety of a product, whether it is a pharmaceutical, biopharmaceutical, medical device or pesticide, may also include demonstrating its genotoxic potential.
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Back to Genetic Toxicology
Point mutations result from small changes in nucleotide sequence, including base-pair substitutions and frameshift mutations, some of which may be detected as changes in the conditions under which the mutant cell can grow. The bacterial mutation assays measure the ability of a test article to induce reverse mutations in selected histidine-requiring mutant strains of Salmonella typhimurium or tryptophan-requiring mutant strains of Escherichia coli. The mammalian mutation assays measure forward mutations at two different loci. These loci control the expression of thymidine kinase (TK) in mouse lymphoma cells or hypoxanthine- guanine phosphoribosyl transferase (HGPRT) in Chinese hamster ovary cells. In order to evaluate the effect of metabolism on the test article, such tests are performed in the presence and absence of exogenous mammalian liver enzyme preparations (S9).
Assays offered by BioReliance:
- L5178Y TK+/- Mouse Lymphoma Assay
- Medical Device and Specialized L5178Y TK+/- Mouse Lymphoma Assays
- Screening Assay Using L5178Y TK+/- Mouse Lymphoma Assay
- CHO/HGPRT Gene Mutation Assay
- In Vivo Mammalian Mutation Assays - Big BlueTM Mutation Assay System
| ICH protocol - Duplicate cultures per dose level |
704 |
| OECD protocol - Single culture per dose level |
700 |
| Single culture per dose level with independent repeat |
700001 |
| OECD protocol - Duplicate cultures per dose level |
702 |
| Duplicate cultures per dose level with independent repeat |
702001 |
| ICH protocol - Duplicate treatment cultures per dose level |
705 |
| Biocompatibility testing of Medical Devices - Screening test |
702201 |
| Biocompatibility testing of Medical Devices - Full test |
702200 |
| Reduced volume modification of the Mouse Lymphoma Assay |
702005 |
| Screening mouse lymphoma protocol |
702006 |
| Duplicate cultures per dose level. |
782 |
| Duplicate cultures per dose level with independent repeat. |
782001 |
| In Vivo Mutagenesis |
170 |
| Sponsor-supplied tissues |
171 |
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