Darryl L. Goss joins Bioreliance
Darryl L. Goss has been appointed Vice
President, Toxicology/Laboratory Animal Diagnostic Services (LADS), a new executive position created to lead this newly
formed Business Unit.
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press release.
Determining the safety of a product, whether it is a pharmaceutical, biopharmaceutical, medical device or pesticide, may also include demonstrating its genotoxic potential.
Cytogenetic analysis provides a valuable technique for evaluation of damage to chromosomes on the basis of direct observation and classification of chromosomal aberrations. Cells arrested in metaphase are examined microscopically for both numerical and structural chromosome aberrations. An alternate cytogenetic approach is the observation of micronuclei, which represent chromosomal-breakage fragments or lagging chromosomes in the cell cytoplasm. The cytogenetic assays may be performed either in vivo or in vitro. In vitro cytogenetic assays are performed in the presence and absence of exogenous metabolic activation systems (S9).
