Biodistribution Services
Biodistribution studies are necessary to provide pre-clinical safety evaluation of novel gene therapy technologies and to address regulatory concerns. They are designed to investigate the integration or expression of the vector construct in the germ line, the persistence of the vector in the target tissues and dissemination to non-target tissues. Quantitative PCR (Q-PCR) is the method of choice for the detection and quantification of specified gene sequences in biodistribution studies. BioReliance is a world leader in the development and application of Q-PCR methods.
By combining the capabilities of our state-of-the-art animal facility and experienced staff, we can undertake a complete biodistribution study. We will ensure that critical assay steps such as nucleic acid extraction from tissues are conducted under the most stringent conditions so that samples are in optimal condition for highly sensitive molecular assays. At BioReliance, these studies are performed in GLP compliant facilities and meet full regulatory requirements.
